Numerical Modeling of Micromixing Performance of Five Generic Microchannel Reactors using Villermaux/Dushman Competing Test Reaction

Document Type : Research Paper


Department of Chemical Engineering, Kermanshah University of Technology, Kermanshah, Iran


Microchannel reactors, known as high-process intensification reactors, are utilized in various fields due to their intensive micromixing performance, which is crucial for fast chemical reactions. The work presented here depicts the Computational Fluid Dynamics (CFD) modeling of five generic microchannel reactors (MCRs), namely T-square, T-trapezoidal, Y-rectangular, concentric, and caterpillar designs based on the experimental published data of the parallel competing Villermaux-Dushman reaction. The main objective of this study is to numerically quantify the effects of the total liquid flow rate (1-18 mL/min), micromixer dimension (150-1600 µm) and configuration on the values of the pressure drop, energy dissipation, mixing time, and segregation index (XS).
The CFD results revealed that under constant concentrations of the reactants ( , , , = 0.091, 0.0224, 0.016, 0.0033 M), the dissipation rate intensified with increasing the total flow rate but weakened with the change in symmetry and the channel diameter. Further, the estimated values of the segregation index illustrated that the caterpillar design could bring about a reasonable enhancement in micromixing performance with energy dissipation (ε) and segregation index of 1335700 W/kg and 0.0024, followed by T-square and Y-rectangular with Xs~ 0.0061 and 0.0161, respectively. The low values of mixing time for caterpillar MCR were found in the range of 0.01-0.1 s for liquid flow rates of 1-18 mL/min.


  1. Arian E, Pauer W. Sucrose solution as a new viscous test fluid with tunable viscosities up to 2 Pas for micromixing characterization by the Villermaux–Dushman reaction. Journal of Flow Chemistry. 2021;11(3):579-88.
  2. Manzano Martı́nez AN, Haase AS, Assirelli M, van der Schaaf J. Alternative Kinetic Model of the Iodide–Iodate Reaction for Its Use in Micromixing Investigations. Industrial & Engineering Chemistry Research. 2020;59(49):21359-70.
  3. Ouyang Y, Xiang Y, Gao X-Y, Zou H-K, Chu G-W, Agarwal RK, et al. Micromixing efficiency optimization of the premixer of a rotating packed bed by CFD. Chemical Engineering and Processing-Process Intensification. 2019;142:107543.
  4. Cheng K, Liu C, Guo T, Wen L. CFD and experimental investigations on the micromixing performance of single countercurrent-flow microchannel reactor. Chinese Journal of Chemical Engineering. 2019;27(5):1079-88.
  5. Fonte CP, Fletcher DF, Guichardon P, Aubin J. Simulation of micromixing in a T-mixer under laminar flow conditions. Chemical Engineering Science. 2020;222:115706.
  6. Clark J, Kaufman M, Fodor P. Mixing Enhancement in Serpentine Micromixers with a Non-Rectangular Cross-Section. Micromachines. 2018;9(3):107.
  7. Hossain S, Afzal A, Kim K-Y. Shape optimization of a three-dimensional serpentine split-and-recombine micromixer. Chemical Engineering Communications. 2017;204(5):548-56.
  8. Fletcher D, Avila M, Poux M, Xuereb C, Aubin J. CFD Modelling of Micromixing in a T-mixer with Square Bends. Conference CFD Modelling of Micromixing in a T-mixer with Square Bends.
  9. Frey T, Schlütemann R, Schwarz S, Biessey P, Hoffmann M, Grünewald M, et al. CFD analysis of asymmetric mixing at different inlet configurations of a split-and-recombine micro mixer. Journal of Flow Chemistry. 2021;11(3):599-609.
  10. Wang D, Ye G, Mai J, Chen X, Yang Y, Li Y, et al. Novel micromixer with complex 3D-shape inner units: Design, simulation and additive manufacturing. Computer Modeling in Engineering & Sciences, 123 (3). 2020:1061-77.
  11. Zhendong L, Yangcheng L, Jiawei W, Guangsheng L. Mixing characterization and scaling-up analysis of asymmetrical T-shaped micromixer: Experiment and CFD simulation. Chemical Engineering Journal. 2012;181:597-606.
  12. Bertrand M, Lamarque N, Lebaigue O, Plasari E, Ducros F. Micromixing characterisation in rapid mixing devices by chemical methods and LES modelling. Chemical Engineering Journal. 2016;283:462-75.
  13. Ouyang Y, Xiang Y, Zou H, Chu G, Chen J. Flow characteristics and micromixing modeling in a microporous tube-in-tube microchannel reactor by CFD. Chemical Engineering Journal. 2017;321:533-45.
  14. Li W, Xia F, Qin H, Zhang M, Li W, Zhang J. Numerical and experimental investigations of micromixing performance and efficiency in a pore-array intensified tube-in-tube microchannel reactor. Chemical Engineering Journal. 2019;370:1350-65.
  15. Guo M, Hu X, Yang F, Jiao S, Wang Y, Zhao H, et al. Mixing Performance and Application of a Three-Dimensional Serpentine Microchannel Reactor with a Periodic Vortex-Inducing Structure. Industrial & Engineering Chemistry Research. 2019;58(29):13357-65.
  16. Rahimi M, Aghel B, Hatamifar B, Akbari M, Alsairafi A. CFD modeling of mixing intensification assisted with ultrasound wave in a T-type microreactor. Chemical Engineering and Processing: Process Intensification. 2014;86:36-46.
  17. Ouyang Y, Xiang Y, Gao X-Y, Zou H-K, Chu G-W, Agarwal RK, et al. Micromixing efficiency optimization of the premixer of a rotating packed bed by CFD. Chemical Engineering and Processing - Process Intensification. 2019;142:107543.
  18. Kashid M, Renken A, Kiwi-Minsker L. Mixing efficiency and energy consumption for five generic microchannel designs. Chemical engineering journal. 2011;167(2-3):436-43.
  19. Guichardon P, Falk L, Villermaux J. Extension of a chemical method for the study of micromixing process in viscous media. Chemical Engineering Science. 1997;52(24):4649-58.
  20. Rahimi M, Azimi N, Parsamogadam MA, Rahimi A, Masahy MM. Mixing performance of T, Y, and oriented Y-micromixers with spatially arranged outlet channel: evaluation with Villermaux/Dushman test reaction. Microsystem Technologies. 2017;23(8):3117-30.
  21. Unadkat H, Nagy Z, Rielly C. Investigation of turbulence modulation in solid–liquid suspensions using parallel competing reactions as probes for micro-mixing efficiency. Chemical Engineering Research and Design. 2013;91(11):2179-89.
  22. Soleymani A, Kolehmainen E, Turunen I. Numerical and experimental investigations of liquid mixing in T-type micromixers. Chemical Engineering Journal. 2008;135:S219-S28.
  23. Nie A, Gao Z, Xue L, Cai Z, Evans GM, Eaglesham A. Micromixing performance and the modeling of a confined impinging jet reactor/high speed disperser. Chemical Engineering Science. 2018;184:14-24.
  24. Falk L, Commenge J-M. Performance comparison of micromixers. Chemical Engineering Science. 2010;65(1):405-11.
  25. Jafari O, Rahimi M, Kakavandi FH. Liquid–liquid extraction in twisted micromixers. Chemical Engineering and Processing: Process Intensification. 2016;101:33-40.
  26. Fournier M-C, Falk L, Villermaux J. A new parallel competing reaction system for assessing micromixing efficiency—determination of micromixing time by a simple mixing model. Chemical Engineering Science. 1996;51(23):5187-92.
  27. Benz K, Jäckel KP, Regenauer KJ, Schiewe J, Drese K, Ehrfeld W, et al. Utilization of micromixers for extraction processes. Chemical Engineering & Technology: Industrial Chemistry‐Plant Equipment‐Process Engineering‐Biotechnology. 2001;24(1):11-7.
  28. Rahimi M, Valeh‐e‐Sheyda P, Zarghami R, Rashidi H. On the mixing characteristics of a poorly water soluble drug through microfluidic‐assisted nanoprecipitation: Experimental and numerical study. The Canadian Journal of Chemical Engineering. 2018;96(5):1098-108.
Volume 56, Issue 2
December 2022
Pages 257-272
  • Receive Date: 29 August 2022
  • Revise Date: 03 October 2022
  • Accept Date: 06 October 2022
  • First Publish Date: 10 October 2022